Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Bissau (95% of total searches to Guinea-Bissau). The next most popular destinations are Rubane Island (2%) and Mansôa (2%). Searches for hotels in Bubaque (1%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Guinea-Bissau is Bissau. Bolama and Oio are also very popular.
KAYAK users have found double rooms in Guinea-Bissau for as cheap as $34 (Bissau) in the last 3 days. The average price is $131.